Permission Issue
 

When updating a listeners I got this message:

Warning: is_file() [function.is-file]: Stat failed for /etc/httpd/conf/ssl.key/server.key (errno=13 - Permission denied) in /opt/lsws/admin/html.3.0/classes/ConfValidation.php on line 572

Warning: fopen(/opt/lsws/conf/httpd_config.xml) [function.fopen]: failed to open stream: Permission denied in /opt/lsws/admin/html.3.0/classes/ConfigFile.php on line 46

LS is running as apache:apache.

How can I solve this?

You need to make directory /etc/httpd/conf/ssl.key/ accessible for user apache, the server.key file do not need to be readable for user apache for better security.