1) Both Zend Optimizer and Accelerator (different products) modify the "php.ini" file to insert paths to the extensions.
You need to modify the php.ini in the /conf folder of LiteSpeed install and copy those php.ini lines.
To verify, launch a php script under LiteSpeed and do a "echo phpinfo();" in the script to see if the zend extensions has been loaded.
2) Make sure you changed the actual listener port and not the listerner name. Click on "Listeners" and then the "edit" link next to the listener.