On linux Centos 4.2. "rm -rf /tmp/*" as root will not do any harm while LiteSpeed is running.
The /tmp/lshttpd is not effected/removed.
You can however cd into /tmp/lshttpd and remove swap but it will be created automatically when needed.
However, just because you could doesn't mean you should or it will work 100%. Basically, it works and doesn't appear to do any harm but use at your own risk as the clear-and-burn approach might not work in the future.