We enabled WHM/cPanel open_basedir, one site already had issues with it. A series of includes to take a site forums info and put it on the front page. Includes like include "forums/blah/bluuu.php" and required "conf_global.php; in the forums dir which the conf was also in that dir was now failing too. Code that worked for years. I added a ./ infront of every include, switched require to include_once for some reason required "./blah" caused issues. On a few I did the full path of /home/username/public_html/path/to/php/include Now it works fine. pen_basedir no value no value include_path .:/usr/lib/php:/usr/local/lib/php .:/usr/lib/php:/usr/local/lib/php Yet phpinfo shows the above, so I ignored module they said here http://www.litespeedtech.com/support/forum/showthread.php?t=1033&page=2 and then the home made page went to wonk again Coppermine gallery online users include script uses the below to include config, we got a unable to connect error require ('include/config.inc.php'); The error we got in error_log 8-Jun-2011 00:10:41] PHP Warning: include_once() [<a href='function.include'>function.include</a>]: Failed opening '/home/boo/public_htmlrenders/include/config.inc.php' for inclusion (include_path='.:/usr/lib/php:/usr/local/lib/php') in /home/boo/public_html/renders/onlinestats_external.php on line 23 We ended up using include_once $_SERVER['DOCUMENT_ROOT'] . '/renders/include/config.inc.php'; Is this similar to your problem?